Services & Expertise

Services

• Drug target identification and characterization
• Computational drug discovery (virtual screening, combinatorial library construction, structure-activity modeling)
• Computer-aided hit-to-lead optimization (ADME and Toxicity prediction, bioavailability and selectivity optimization)
• Rapid and comprehensive evaluation of novel small molecules and biologics in preclinical model systems including:
  • Cytotoxicity assays
  • Clonogenic assays
  • Biomarker assays (established or novel)
  • Drug-target and off-target interaction assays
  • Drug-drug interactions
  • In Vitro and In Vivo tumour cell lines
  • GC and LC-MS assays for a variety of chemistries in biological matrices for GLP studies
• Biomarker assay development
• Single agent studies and combination studies
• Pharmacodynamic and biomarker analysis of novel drugs in human clinical trials
• Circulating Tumour Cell (CTC) analysis in human clinical trials

The Living Tumor Laboratory

The Living Tumor Lab is a unique and valuable resource, which grows a wide variety of patient-derived cancer tissues, including both low and high-grade solid cancers.

This work enables researchers to readily study human cancer tissue in vivo and develop a variety of transplantable tumour tissue lines that can be used as models for studying cancer growth/progression/metastasis and drug sensitivity.

Visit the Living Tumor Laboratory website

Expertise

Our expert team of scientists and technicians work in a state-of-the-art facility and balance work in research and development, which integrates seamlessly with the PC-TRIADD microarray facility, functional genomics and pathology service, as well as the clinical trials unit, to realize a comprehensive and focused translational research centre.